Synthesis and Pharmacological Evaluation of Gastro-sparing Mutual Prodrug of Aceclofenac with Glucosamine

Suneela S. Dhaneshwar * 1, Sanal Dev1, B.Rathi2 and S. L. Bodhankar2
1 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy,
Erandwane, Pune, India.
2 Department of Pharmacology, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune, India.
*Author for correspondence: Dr. Suneela Dhaneshwar E-mail: suneeladhaneshwar@rediffmail.com

InPharm Communique Vol 2, No 3 | 17

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ABSTARCT 

Aceclofenac is a nonsteroidal antiinflammatory drug that is used to relieve pain and inflammation in arthritic conditions like osteoarthritis, rheumatoid arthritis and ankylosing spodylitis. Aceclofenac is known to induce erosion and ulcers in the gastrointestinal tract but in contrast to other nonsteroidal anti-inflammatory agents, it has shown stimulatory effects on cartilage matrix synthesis. In order to lower the ulcerogenic potential and enhance effectiveness of aceclofenac as antiarthritic agent, a mutual prodrug was synthesized with neutraceutical carrier D-glucosamine that has shown to stimulate the biosynthesis of glucosaminoglycans and hyaluronic acid backbone needed for the formation of the proteoglycans found in the structural matrix of joints. The study showed that the prodrug not only lowered the ulcerogenic potential of aceclofenac but also enhanced its analgesic, antiinflammatory and antiarthritic activities thus proving the utility of D-glucosamine as an effective carrier in mutual prodrug synthesis. Key words Aceclofenac, anti-arthritic, anti-inflammatory, glucosamine, gastrosparing, mutual prodrug.

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